When planning your trip to Venice, accommodation will be one of the first things you organize. Make sure you know which area of the city you want to stay in before you book with these outlines of each of the main neighborhoods:
Cannaregio is one of those neighbourhoods that you stay in if you get to Venice and want to 'live like a local'. This area is close to slightly off-beat places like one of the oldest Jewish ghettos in Europe, the church of Santa Maria Dei Miracoli, and the Church of Madonna dell'Orto
If you don't know what San Marco is before you go to Venice, you will not leave without finding out. San Marco is the tourist hub of Venice, and it is the area that will get you closest to all the famous sights. This is not the area to stay in if you are on a budget- accommodation can sky rocket for the convenience of the location, and food is relatively expensive and not that great (plus it can be difficult to find supermarkets close by to keep your food budget down)
Castello is another area of Venice that is similar to Cannaregio. |An authentic Venetian feel full of locals who are just going about their daily lives. The area is close to ferry stop and hence easy to catch the ferry to Murano and Burano islands. However, Castello is a bit further away from the key tourist sites.
Venice is not known for having a nightlife, but if it did, it would be in Dorsoduro. This is an area that is frequented by a slightly younger crowd.
Santa Croce is the least 'touristy' area of Venice, so if you really don't like crowds then this might be the place for you. Accommodation is relatively cheap. However, you might be spending a bit more on public transport or walking a lot.
San Polo is known as one of the oldest neighbourhoods in Venice, and it is among the most touristy as it is where the Rialto Bridge is located.